Antagonism between retinoic acid receptors.
نویسندگان
چکیده
منابع مشابه
Retinoic Acid Receptors in Myeloid Leukemia: Characterization of Receptors in Retinoic Acid-Resistant K-562 Cells
Although mRNA for the retinoic acid receptor a (RAR-a) is expressed in many different myeloid leukemias, most of these leukemia cells exhibit little if any phenotypic response when exposed to retinoic acid (RA). To determine whether such RA resistance is related to altered RA receptor structure or function, we performed a detailed analysis of nuclear RA receptors in RA-resistant K-562 cells. Th...
متن کاملRetinoic acid receptors in myeloid leukemia: characterization of receptors in retinoic acid-resistant K-562 cells.
Although mRNA for the retinoic acid receptor alpha (RAR-alpha) is expressed in many different myeloid leukemias, most of these leukemia cells exhibit little if any phenotypic response when exposed to retinoic acid (RA). To determine whether such RA resistance is related to altered RA receptor structure or function, we performed a detailed analysis of nuclear RA receptors in RA-resistant K-562 c...
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Retinoic acid (RA) triggers antiproliferative effects in tumor cells, and therefore RA and its synthetic analogs have great potential as anticarcinogenic agents. Retinoic acid receptors (RARs) mediate RA effects by directly regulating gene expression. To define the genetic network regulated by RARs in breast cancer, we identified RAR genomic targets using chromatin immunoprecipitation and expre...
متن کاملRetinoic acid repatterns axolotl lateral line receptors.
The effects of all-trans retinoic acid on the development of the lateral line placodes of axolotls was studied. Late gastrula and early neurula were exposed to 10(-7) to 10(-5) M retinoic acid for one hour and then reared until they would normally be feeding larvae. As in other vertebrates, the extent of the developmental abnormalities is concentration dependent. Those embryos exposed to the hi...
متن کاملDevelopmental expression of retinoic acid receptors (RARs)
Here, I review the developmental expression features of genes encoding the retinoic acid receptors (RARs) and the 'retinoid X' or rexinoid receptors (RXRs). The first detailed expression studies were performed in the mouse over two decades ago, following the cloning of the murine Rar genes. These studies revealed complex expression features at all stages of post-implantation development, one re...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1991
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.11.8.4097